11 The equivalent prior time period for Novo Nordisk was 11/13/10 at which point their market cap was $72.2 bn, equaling a $56.7 bn gain to the reference time point of 12/5/17 (Ozempics launch)
However, the use of continuous glucose monitoring (CGM) has highlighted that hypoglycemia occurs much more frequently (closer to 30%) and is observed with similar frequency in both RYGB and VSG (23, 177, 230)
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Conclusions DPP-4 inhibitors are important oral antidiabetic agents that are placed as second-line therapy after metformin failure as insulinotropic agents that have no intrinsic hypoglycaemia risk and are body weight neutral