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These include: A large lump under the skin that lasts for more than a few days Oozing from the injection site Ongoing pain or swelling Bleeding that is hard to stop Medication leaking out during the injection Very little or no improvement in blood sugar or weight control after many injections These signs may point to problems like injecting too shallow (into the skin) or too deep (into muscle), or using the wrong technique

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No, NICE does not recommend routine monitoring of inflammatory markers as a target of tirzepatide therapy

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