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These drugs can affect the release of certain neurotransmitters, such as dopamine

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Besides, GLP-1RA NLY01 could significantly reduce the proportion of infiltrating white blood cells (CD45 high ) and monocytes (Clec12a + ) in the central nervous system (CNS), while decreasing the number of effector/memory T cells (CD4 + CD44 + ) and inhibiting inflammation in peripheral circulation and CNS (90)

doi: 10.3389/fendo.2018.00706 74 MahboobifardFBidari-ZerehpooshFDavoudiZPanahiMDargahiLPourgholamiMHet al

This imbalance can lead to oxidative-mediated central nervous system (CNS) damage, which is further supported by declined cognitive abilities and more severe depressive symptoms in these individuals

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