deficiencies of vitamin B12, folate or niacin, and infective causes including cryptococcal meningitis, HIV, Lyme disease, progressive multifocal leukoencephalopathy, subacute sclerosing panencephalitis, syphilis and Whipple's disease
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First, the histidine residue in the sequence creates a stable binding site for the Cu ion this is a classic copper-chelating motif that makes GHK a physiological carrier of this element
Debourdeau, S