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[1] [2] According to NICE guideline NG28 (Type 2 diabetes in adults: management), GLP-1 receptor agonists may be considered when metformin is contraindicated or not tolerated, or when other treatments have not achieved adequate glycaemic control, particularly in patients with a BMI 35 kg/m (or lower in certain ethnic groups) or when weight loss would provide additional clinical benefit

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In addition to controlling appetite, semaglutide slows stomach emptying