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Oestrogen dependence may be due to the upregulation of the 17-hydroxysteroid dehydrogenase-1 and aromatase genes, whereas progesterone resistance may result from the failure of progesterone receptor activation and transcription of progesterone target genes [99]

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Many mammals evolved smaller body sizes as an adaptation to ecological stresses, such as food scarcity, enabling faster reproduction that promoted species survival and evolution

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