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2.4.2 Trial 2 (Digoxin/Metformin) Sample Size Calculations Assuming the ratio between AUC values was 1.03, and the number of subjects where both primary endpoints were evaluable was 28, then the combined power of concluding no effect of coadministration of oral semaglutide for both endpoints was at least 95%

80 Nevertheless, it is well-established that exceeding the usual concentration of exogenous D-galactose can cause oxidative stress, apoptosis, and inflammation, producing aging effects in several organs, including the brain

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doi:10.1016/j.ejphar.2020.173368 Yilmaz H, Sahin S, Sayar N, et al

Tao W, Wang N, Ruan J, Cheng X, Fan L, Zhang P, et al

endocytosis and phagocytosis) to more fully explore the impact of lysosomotropic agents on cellular processes