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Blocking the ERK pathway with specific inhibitors also nullified NACs protective effects against A toxicity

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Although VSMCs and the kidney play integral roles in BP regulation, there were no baseline differences in systolic, diastolic, or mean arterial pressure (MAP) between Glp1r VSM+/+ and Glp1r VSM/ mice, despite a marked reduction in kidney and renal artery Glp1r expression in Glp1r VSM/ mice (Figure 2, AC)