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The evidence base for tirzepatide as monotherapy is robust, with pivotal trials including SURMOUNT-1 demonstrating significant weight reduction in adults with obesity, and SURPASS trials establishing glycemic efficacy in type 2 diabetes

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Chronic activation of the hypothalamic-pituitary-adrenal (HPA) axis leads to prolonged elevation of cortisol, which can downregulate serotonin and dopamine receptor expression in areas such as the prefrontal cortex and limbic system, contributing to mood disorders and impaired cognitive function

Cytokine Growth Factor Rev (2022) 66:1525

2012 Sep;11(3):204-11

Rates of statin use tended to be lower in ALT responders than in non-responders (26.7% vs