Possible effects of uremic toxins p-cresol, indoxyl sulfate, p-cresyl sulfate on the development and progression of colon cancer in patients with chronic renal failure
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DHODH activity is essential for proliferating cells owing to their increased demand for nucleotides, and DHODH inhibition has long been studied as a therapeutic strategy in autoimmune diseases (for example, via leflunomide) and cancer, where it can lead to cell cycle arrest, DNA damage and replication stress 42,44,45
Alternative markers such as cystatin C-based eGFR or enzymatic creatinine assays may provide more accurate assessment when clinical concern exists, as recommended in KDIGO guidelines
In controlled research environments, it is studied for its involvement in receptor-mediated signaling, peptide-regulated cellular activity, and tissue-focused biochemical models
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