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The question of whether GLP-1 receptor agonists might increase pancreatic cancer risk emerged from preclinical animal studies and early post-marketing surveillance reports

24 This can be due to differences in the specific drug used, the dosage, the duration of the study, the characteristics of the participants (age, baseline health) 9 , the methods used to measure body composition (DXA, BIA, MRI all have different strengths and weaknesses) 16 , and whether interventions like dietary counseling (especially protein emphasis) and exercise were included

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For tirzepatide, patients should be advised that oral contraceptive effectiveness may be reduced during initiation and dose escalation

For trainees and clinician-scientists, this is a reminder that therapeutic innovation and health economics are inseparable

Regular follow-up appointments are important to assess for any changes in health status and consider alternative or additional interventions to maintain health improvements achieved during treatment