Caloric restriction reduces glucose availability to the brain, alters hormone levels, and can impair neurotransmitter synthesis
The most common adverse effects include gastrointestinal symptoms such as nausea, vomiting, diarrhoea, and constipation, which typically diminish over time
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The addition of high dose niacin was intended to increase HDL ("good") cholesterol, reduce elevated triglycerides, and, most importantly, reduce the risk of heart attacks and stoke
There is an increased risk of GH-related side effects, but these are rare when used correctly