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This treatment works in part because the healing process leads to beneficial scar tissue formation which "tacks" the loose hemorrhoidal tissues to the underlying rectal wall and reduces blood flow into the remaining hemorrhoidal channels

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Applying the GPX4 inhibitor RSL3 or knocking down GPX4 can enhance cell lipid peroxidation, while FSP1 overexpression attenuates RSL3-induced lipid peroxidation

Hummers WS, Offeman RE

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* Correspondence: Laura Trov [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers