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The deviation from linearity is probably due to geometric constraints in the roGFP barrel similar to those described for roGFP1-iR which had been expected to be less reducing than roGFP1-iL due to stabilization of the thiolate anion by the introduced adjacent basic arginine residue (Lohman and Remington, For live cell measurements biosensors should ideally exhibit a strong preference for one specific analyte

Both NNC0090-2746 (107) and tirzepatide (63) delivered clinically meaningful improvements in glycemic control and body weight reduction in their phase 1 trials

Nat Rev Neurosci 9:4656 DiSabato D, Quan N, Godbout J (2016) Neuroinflammation: the devil is in the details

Eating sulfur-rich vegetables may lower oxidative stress by raising glutathione levels, according to several human and animal studies

Kaiya et al., 2002)

The association of fecal microbiota and fecal, blood serum and urine metabolites in myalgic encephalomyelitis/chronic fatigue syndrome