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What stood out was the lack of major difference between agents, suggesting that while GLP-1-based therapies as a class have a relatively higher risk of [GI] events compared with other glucose-lowering drug classes, there do not appear to be substantial safety differences within the class itself, Alkabbani told Healio

Semaglutide labeling includes a boxed warning about thyroid C-cell tumors based on animal findings, and it lists personal or family history of medullary thyroid carcinoma or MEN2 as a contraindication

SGLT-2 inhibitors reduce the risk of cerebrovascular/cardiovascular outcomes and mortality: a systematic review and meta-analysis of retrospective cohort studies