CHDH SNPs lower activity, with impacts on cell membrane, mitochondrial structure, sperm concentration and motility, foetal development, and increasing risk of NAFLD (as choline is a key constituent of bile)
Clinical trials show the drug can help people improve the way their body handles sugar
doi: 10.1016/S0021-9258(18)99388-9 150
Following your doctors guidelines is recommended to avoid complications
For example, protein sources which are high in micronutrients such as vitamin B12, zinc, choline, and selenium (e.g., whole eggs) appear to better support muscle growth and repair compared to protein sources lower in micronutrients (e.g., egg whites) indicating a synergistic relationship
For breastfeeding individuals, these insights do not predict exact medication response or safety, but may contextualize your metabolic profile and inform provider discussions about timing and alternatives