We thus believe the reinterpretation of the physiology of vitamin B 12 deficiency that accounts for cysteine-block has several implications for clinical studies and drug discovery
Adding multiple compounds increases complexity, cost, and the potential for interactions
Research reveals that senescent cells show upregulation of pro-apoptotic initiators PUMA and BIM while anti-apoptotic guardian BCL-2 is reduced, suggesting these cells are ready to undergo apoptosis but the execution is restrained by the FOXO4-p53 interaction
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Because of the hypothesised abnormalities in oxidative stress and suggested links between initial inflammation, glutamate excitotoxicity and neuronal dysfunction/loss [25], our additional interest was in, GSH, glutamate and glutamine, and total choline as biomarkers of these processes
(2022) 378:e072117