Healthcare providers should assess: Body composition changes (not just weight) to evaluate muscle mass preservation Glycemic control in patients with diabetes, adjusting other medications as needed Thyroid function if symptoms of hypothyroidism develop (fatigue, cold intolerance) Nutritional status through clinical assessment and laboratory testing when indicated Patients experiencing excessive fatigue, cold intolerance, or other symptoms potentially indicating metabolic suppression should be evaluated promptly, though these symptoms more commonly relate to rapid weight loss itself rather than direct drug effects
This means it mimics the action of GLP-1 by binding to and activating GLP-1 receptors in the body
Biochimica et Biophysica Acta, 1822 (5), 625
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Genetic Predispositions in GLP-1 and GIPR Pathways Linked to Tolerability Emerging research suggests specific genetic variants influence how well individuals tolerate GLP-1 medications
