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Acknowledgements The authors thank Michael Bonar, Creative Director at the Leicester Diabetes Centre, for the original figure concept

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Ongoing research includes: long-term pancreatic studies thyroid cancer surveillance 5-year cardiovascular follow-ups GI motility research safety monitoring for chronic users registries for severe GLP-1 complications FDA GLP-1 Warnings When to Call a Doctor Immediately Seek medical attention if you experience: severe abdominal pain persistent vomiting dehydration rapid weight loss inability to eat jaundice sharp back or flank pain little or no urine output These may indicate long-term GI damage, pancreatitis, or kidney injury

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