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Combining agents without understanding their cumulative impact could increase this risk

These may range from sedation to coma

It leads to a delay of gastric emptying, improved glycemic control, and a reduction of feelings of hunger and food craving [21]

Our current findings in aging or HFD-fed mice with abrogation of improved lipid tolerance, despite reduced DPP-4 activity and increased GLP-1 levels, suggest that the concept of GLP-1 resistance should be further explored in studies examining the GLP-1dependent control of TG excursion

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