In the absence of stomach and gastric acid, the damaging effects of cysteamine (400 mg/kg s.c., sacrifice 24 hours thereafter), so far thought to be an acid related duodenal ulcerogen, and the cytoprotective effects of NaBPC157 (10 g or 10 ng/kg i.p.) were further challenged in comparison with reference agents (cimetidine (50), ranitidine (10), omeprazole (10), bromocriptine (10) and atropine (10) (values given in mg/kg i.p., 1 hour before cysteamine)) known also to be cytoprotective
A structural explanation for these findings was provided from our previous cryo-EM structures of CT(Pro32) and rAmy(Tyr37)-bound AMYRs structures where the bulky phenolic side chain of Y37 rAmy forms perpendicular stacking interactions with W79 ECD 15 , and additional interactions with the respective RAMP protomer that are likely important for selectivity of rAmy for AMYRs over CTR
A primary mechanism is its profound influence on gene expression
These peptides help support natural processes such as healing, metabolism, hormone regulation, energy production, and cellular repair
E., Ramos, S
Chang C, Worley BL, Phaton R, Hempel N
