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NNMT is a metabolic enzyme that regulates cellular energy and methylation potential by preventing NAM (Nicotinamide) from participating in the NAD+ Salvage Pathway and converting back into NAD+

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Although Luxturna is approved for use in correcting RPE65 -induced retinal degeneration, only 12% of RP patients and 616% of Leber congenital amaurosis (LCA) patients have mutations that are treatable using this approach [36, 37]

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"I'm anticipating we'll know where these peptides sit in the recategorization by November or December," Husain says