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CVB has been reported to infect multiple human cell types associated with T1D, including primary islets, human pluripotent stem cell-derived islets, ductal cells, thymic epithelial cells, thymic fetal cells, and human PBMCs (115, 140149)
Overall prescribing rates (GLP-1 RA prescriptions per total prescriptions) in September 2025 remained stable relative to June 2025 (+4.6%)
Addressing these unresolved questions may improve receptor-level specificity, strengthen mechanistic interpretation, and enhance experimental clarity across melanocortin signaling investigations
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The labeled titration schedule remains the operative instruction [6]