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Materials and Methods Animals Experiments were conducted in agreement with the NIH guidelines for the humane treatment of animals and were approved by the local Animal Care and Use Committee (Comisso de tica em Cuidado e Uso AnimalInstituto de Qumica, USP) (Permit number: 21/2014)

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The mean percentage of body weight loss at 72 weeks was 15.0% at the lowest dose, and 20.9% in the highest dose cohort (compared to 3.1% in placebo) (NCT04184622)