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GLP-1 agonists, such as semaglutide (Ozempic, Wegovy) and tirzepatide (Monjaro, Zepbound) have become powerful tools for weight loss and metabolic health
Red flag symptoms requiring urgent medical attention include reduced urine output with swelling (suggesting acute kidney injury), blood in the urine (haematuria), fever with urinary symptoms (indicating possible pyelonephritis), or signs of severe dehydration such as dizziness, confusion, or rapid heartbeat
Although there was no significant improvement in glycaemia with efinopegdutide, this was explicable given that the participants had normal glycaemia at baseline
For those participating in a clinical trial, all adverse effects even those that seem minor should be reported to the trial team as part of the pharmacovigilance process
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