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Glutamine metabolism can be targeted by inhibiting glutaminolysis, employing combination therapies, suppressing c- MYC expression, inhibiting GDH, depleting the glutamine supply, inhibiting glutamine uptake, and exploiting glutamine analogs

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HEK-GLP-1R cells or wild-type HEK-293 cells were grown in ELISA 8-well strips (96-well format) and used either with or without loading with the Ca2+ indicator, fluo-4 as indicated