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10.1210/jc.2009-0921 87

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Atherosclerosis Atherosclerosis it a pathological condition characterized by the buildup of plaque, composed of fats, cholesterol, calcium and other substances, within the intima of large and medium-sized arteries- This process begins with the activation of endothelial cells, setting off a cascade that leads to vessel narrowing, activation of inflammatory pathways, and ultimately, formation of atheromatous plaques [443]