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FIGURE 1 The synthesis of GSH from its constituent amino acids occurs exclusively in cytosol, where -GCS and GS reside
Subsequently, lysophosphatidylcholine acyltransferase 3 (LPCAT3) esterifies these derivatives with phosphatidylethanolamine (AA-PE), forming a crucial intermediate [92,93,94]
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Thus, the intracellular signaling which results in hepatocyte necrosis after APAP could also influence inter-cellular communication through various gap junction proteins and further research in this area will provide additional insight into the transmission of APAP- induced signaling across the liver
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(Cham: Springer International Publishing), 137158
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