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[1] [8] This mechanism underlies strict warnings that MB should not be administered alongside selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), certain tricyclic antidepressants, or other MAO inhibitors, except in life-threatening situations

However, if you experience any stomach discomfort, taking them with a light meal is a perfectly acceptable alternative

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This usually settles within a week or two

Vegetarians and vegans may need to take an over-the-counter B12 supplement to ensure they're getting enough, but people with vitamin B12 absorption issues may require prescription B12 injections

How B12 Deficiency Manifests as Neuropathy Not enough vitamin B12 can hurt the nerves