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It has been shown using various atherosclerosis animal models that GLP-1RA therapy is associated with a reduction in atherosclerotic plaques, prevention of aorta intima-media thickening, improvement in vascular endothelial function, reduction of the necrotic zone and an increase of the fibrous component in the plaque and plaque stabilisation

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doi: 10.1155/2022/8744788 3

FIGURE 1 Estrogens play a multifaceted role in the central nervous system (CNS), influencing synaptic plasticity, neuronal development, and survival in newly formed spinal synapses, as well as promoting neural stem cell proliferation and maintaining the integrity of the blood-brain barrier (McCullough et al., 2003