reduction in sustained decline in eGFR, kidney disease progression or end-stage kidney disease) and the tolerability of SGLT2is across the CKD spectrum [10,11,12]
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However, glomerular cell reach and liver avoidance pose challenges [74]
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Dosing and measurement errors come first: the FDA describes adverse event reports involving mistakes in measurement and administration, some requiring hospitalization, and prescribing of doses beyond what the approved label supports higher single doses, more frequent administration, faster titration
Scientists are also targeting metabolic functions beyond cholesterol, because the brain handles energy differently as Alzheimers disease develops