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Mechanism 3: ROS Scavenging and MITF Suppression UV radiation generates reactive oxygen species that activate the Microphthalmia-associated Transcription Factor (MITF), the primary transcriptional regulator of tyrosinase gene expression

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doi: 10.1093/humupd/dmz012 3 FengJZhangSChenJYangJZhuJ

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Collectively, these findings suggest that the transmission of peripheral inflammation to the central nervous system, and its self-sustaining nature within the brain, may constitute a central potential mechanism linking acute exacerbations of PEM with long-term cognitive consequences