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But is it safe to research

They can be prescribed by physicians for approved indications and sometimes for off-label use (when the physician determines its medically appropriate)

Owing to the lack of robust clinical data, clinicians and healthcare systems may not be equipped to identify or manage adverse effects associated with these molecules

6 Delivery of flavonoids using novel strategies 6.1 Topical delivery strategies for flavonoids Innovative transdermal delivery systems have demonstrated measurable improvements in enhancing the topical bioavailability of poorly soluble agents

doi: 10.1016/S0009-8981(03)00200-6