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Animal and human studies demonstrate that lean individuals have different and more diverse types of bacteria than obese individuals

Available anti-VEGF drugs include bevacizumab, ranibizumab and aflibercept

In the randomized placebo-controlled HOME trial of 390 adults with type 2 diabetes (de Jager and colleagues, Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency, BMJ, 2010), metformin lowered serum B12 by a mean of 19 percent over 4.3 years

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The report, ordered under the FAA Reauthorization Act of 2024, says current science, dose models and operational tools provide a sufficient basis for the agency to begin tracking cumulative exposure while additional research continues