Those who continued on tirzepatide experienced additional weight loss instead
However, it is only a matter of time before we will have more definitive answers
Semaglutide's effectiveness lies in its dual action: it slows down stomach emptying to induce a feeling of fullness sooner and remains active in your body longer, thus maintaining appetite control and managing blood sugar levels
Discontinuation rates due to adverse events were higher in the active treatment groups compared with placebo, particularly at higher doses, though the overall discontinuation rate remained relatively modest
Biologie Cellulaire 97 , 270289 (2019)
A biomarker that shifts in the expected direction feels like progress, and it can justify advancing a program, but it is evidence of activity, not of efficacy