The good news is that in-vitro data shows that MAP does convert , but the bad news is we do not really know if the same is true on real, living human skin
Nevertheless, use of metformin may decrease vitamin B 12 status: a meta-analysis of four short-term intervention trials (up to 4 months duration) in patients with type 2 diabetes found that metformin use decreased serum cobalamin concentrations by 57 pmol/L, which could have clinical implications if such patients have suboptimal vitamin B 12 status (146)
That's significant, especially when you consider that many traditional diets fail to produce lasting results
So they started prescribing it and patients were losing weight
For best outcomes, most patients undergo 48 sessions, spaced weekly or bi-weekly
Additional gaps appear for drugs used diagnostically, e.g