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In clinical application, sirolimus, an outstanding representative of mTOR inhibitors, is widely used to prevent rejection after solid organ transplantation and protect the safety of transplanted organs through its powerful immunosuppressive effect

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In a meta-analysis which found that fatigue/weakness, myalgia/arthralgia, depression, anxiety, memory loss, concentration difficulties, dyspnea, and insomnia, were the most prevalent symptoms (8, 9) ( Figure 1 ), and that the prevalence of long COVID is three times higher among 50-59 year-olds than over-80-year-olds (10)

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DOI 10.1016/0196-9781(86)90148-8 Kovalzon VM, Strekalova TV

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