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ROS has been incorporated into cellular signaling, which may activate mitogenic cellular pathways and proinflammatory processes leading to disruption of renal fibrosis and GPx, which support progressive impairment of renal function [74]

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Intranuclear -catenin binds T-cell factor/lymphoid enhancer factor (TCF/LEF) family members and activates the transcription of genes involved in bone formation (Ma and Hottiger 2016)