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Lastly, a very recent systematic review and network meta-analysis, designed to evaluate the effects of long-term CV safety of DPP-4 inhibitors (and GLP-1 agonists), showed lower risk of MI compared to SU-based therapies when these drugs are administered for more than 1 year [33]

Some may experience: Digestive Issues: Nausea, abdominal cramps, and diarrhea can occur, particularly with high dosages

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This tachyphylaxis occurs with continuous infusion of GLP-1 (154, 157), long acting GLP-1RAs (156), or tirzepatide (151)