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The results showed that treatment with chestnut leaf extract reduced the expression ratio of Bcl-2 and Bax, and an increase in the amount of cleaved PARP and paclitaxel-treated CSCs resulted in significant mitochondrial damage compared to untreated or extract-treated CSCs

The 4-hydroxy metabolite was not mutagenic in a number of in vitro and in vivo assays

Westhaus A, Blumrich EM, Dringen R (2017) The antidiabetic drug metformin stimulates glycolytic lactate production in cultured primary rat astrocytes

But its backed by gene expression studies showing that GHK-Cu modulates over 4,000 human genes, with a significant portion involved in tissue remodeling, antioxidant defense, and stem cell function [3]

Du H, Yan SS