glutathione depletion symptoms of Low and How to Fix It Your Body Is Warning You:

Theoretically possible with chronic high-dose use

[DOI] [PMC free article] [PubMed] [Google Scholar] 29.Tepes M., Gojkovic S., Krezic I., Zizek H., Madzar Z., Santak G., Batelja L., Milavic M., Sikiric S., Kocman I., et al

Nature 444 (7122), 10221023

That is not speculation

Kovalzon and Strekalova, summarizing the field in 2006, were explicit: the link between DSIP and sleep had never been further characterized, in part because of the lack of isolation of the DSIP gene, protein and possible related receptor, and the hypothesis of DSIP as a sleep factor was extremely poorly documented and still weak (Kovalzon & Strekalova, 2006)

This ensures accurate concentration and consistent dosing across the vial's lifespan