Given that all ZDHHC family members contain highly conserved DHHC catalytic structural domains, systematic off-target effect assessment must be performed in the design of selective inhibitors, a critical step that will effectively address the problem of non-specific inhibition caused by structural homology
[1] Other symptoms may include thickening of the skin on the shins, known as pretibial myxedema, and eye bulging, a condition caused by Graves' ophthalmopathy
The role of co-infections and secondary infections in patients with COVID-19
is limited
We excluded systematic reviews, meta-analyses, review articles, conference abstracts, correspondences, letter to the editor, animal studies, commentaries and book chapters from the review
Keywords: DPP-4 inhibitors, SAR, heterocyclic scaffolds, bio-activity 1