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10.1021/acs.nanolett.0c02463 171 RuanC.WangC.GongX.ZhangY.DengW.ZhouJ.et al (2021)

We hope that this review has clarified how a balance can be achieved among complexity, realistic physiology, and ease of use of different models

Key Mechanisms of DDIs 1 Metabolic DDIs (CYP450) Inhibition increased exposure & toxicity Induction reduced exposure & loss of efficacy Example: CYP3A inhibitors increasing statin levels myopathy risk

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