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Neuroprotective Research: Preclinical studies have shown that ghrelin and ghrelin receptor agonists can mitigate neuroinflammation, reduce vascular injury, and minimize neuronal apoptosis, suggesting potential applications beyond metabolic effects
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Without human trials, the safety profile, effective dose, and clinical benefit in humans are all unknown
With aging, accumulated oxidative damage leads to a decline in granulosa cell autophagy
The metabolic change affects the balance of pro-inflammatory and anti-inflammatory cytokines and other immune factors, promoting the decline of the gut epithelial barrier
Others may present with skin rashes or nausea, vomiting, and appetite loss
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