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Some researchers use both, with topical for local effect and injection for systemic support

While GHK-Cu focuses on the long-term structural integrity and look of the skin, BPC-157 acts as the immediate first responder

In addition to venous occlusion-induced lesions (Vukojevic et al., 2018

In a rat model of intervertebral disc degeneration, MOTS-c injection preserved disc height (82.4% versus 58.7% in the untreated group), restored MRI signals indicating improved disc hydration, and reduced histological degeneration scores by 44% compared to untreated controls

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Yes, lyophilized (freeze-dried) vials do best refrigerated at 3646F (28C), tolerate cool room temperature for short periods, and last longest frozen at -20C (-4F) or colder