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Cognitive behavioural therapy specifically adapted for eating disorders (CBT-ED) has the strongest evidence base, with studies demonstrating significant reductions in binge eating frequency and improvements in psychological wellbeing

Less common : gallbladder issues, raised heart rate, pancreatitis (rare)

Purinergic Signal 12(1):161174 Bosch-Morell F et al (2020) Medicinal plants and natural products as neuroprotective agents in age-related macular degeneration

doi: 10.1074/jbc.272.7.4108 85 KoltermanOGKimDDShenLRugglesJANielsenLLFinemanMSet al

This is normal thermodynamics, not medication failure

It sits at the intersection of hormones, metabolism, and, for many women, long-term skin and hair concerns