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Biomarker qualification: evidentiary framework

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The peripheral neuropathy in Fabry disease is described as a small fibre neuropathy, meaning that small, unmyelinated nerve fibres are particularly affected [82]

The popeye domain containing genes and their function as cAMP effector proteins in striated muscle

When the thyroid is surgically removed, patients must rely on synthetic levothyroxine (Synthroid) or liothyronine (Cytomel) to maintain these functions

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