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Mechanism of oxidative stress in IBD While the precise mechanisms responsible for the development of IBD remain unclear, it is widely accepted that multiple factors contribute to its etiology, including overproduction of ROS, damage to biomolecules, mitochondrial dysfunction, recruitment of immune cells, impaired antioxidant defense system, and the activation of inflammatory pathways ( Figure 1 )
Sweeney MD, Montagne A, Sagare AP, Nation DA, Schneider LS, Chui HC, et al
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Evaluation of the risk of fracture in type 2 diabetes mellitus patints with incretins:an updated meta-analysis
Clinical trials in Alzheimers disease Alzheimers disease is where the 2025 data forced the largest revision, and where the contrast between observational promise and trial outcome is sharpest
10.4254/wjh.v12.i5.184 43 KonosicS.PetricevicM.IvancanV.KonosicL.GoluzaE.KrtalicB.et al (2019)
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