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Terms with an adjusted P 1 of the RRM2 gene in the PTC tissues was used as the cut-off point for the expression level to classify the samples into the high-expression group and the low-expression group, and further analyses showed that, as shown in Supplementary Table 2 , we found that the RRM2 expression level was correlated with tumor size (P = 0.0048), which may indicate that RRM2 acts as a potential oncogenic factor in PTC

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