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Work from their labs and others led to the development of novel therapeutics to control insulin secretion in Type 2 diabetes based on understanding the action of GLP1 and its metabolism by the enzyme, DPP4, leading directly to the development of the DPP-4 inhibitors for diabetes therapy

Of note, the role of -arrestins in GLP-1R trafficking is unclear, as loss of -arrestin-1 does not affect GLP-1R internalization 14,34

Birth defects occur in 3-4% of pregnancies among women with these conditions versus 2-3% in the general population

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18, 254259.10.1094/MPMI-18-0254 10 FrendoP.JimnezM

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